Saliva

• Definisi

  Cairan kompleks yang diproduksi oleh kelenjar khusus dan disebarkan ke dalam cavitas oral.

• Kelenjar saliva mayor:

  • parotis → duktus Stensen → serous

  • submandibula → duktus Wharton → mucousserous

  • sublingua →duktur Bartholin →serousmucous=

    Serous demilunes, also known as Crescents of Giannuzzi or Demilunes of Heidenhain, are cellular formations in the shape of a half-moon (hence the name "demilune") on some salivary glands. Serous demilunes are the serous cells at the distal end of mucous tubuloalveolar secretory unit of certain salivary glands.

• Kelenjar saliva minor:

  • Glandula bukalis
  • Glandula palatinalis
  • Glandula lingualis
  • Glandula labialis

• Komposisi Saliva

  • Organik
    • Protein
    • Hormon
    • Gas
    • Immunoglobulin
  • Anorganik
    • Sodium
    • Potassium (k)
    • Khlorida
    • Bicarbonat (a)

• Fungsi saliva

  • Teeth
    • Buffering - bicarbonate phosphate
    • Lubrication (proline-glico)
    • Remineralization (Ca, P, F, Statherin) - Statherin, proline rich protein
    • Inhibit of demineralization → Mucin
  • Food
    • Digestive ... ase (enzyme)
    • Taste -zinc
    • Bolus -mucins
  • Bolus
    • Antibacterial → Lactoferrin
    • Antifungal → Histatin - Hifa
    • Antivirus → Cystatin

• Mekanisme

  granula ssekretorik (zymogen) yang mengandung enzim-enzim saliva dikeluarkan dari sel-sel asinar ke dalam duktus.

  simpatis? <<

  parasimpatis >>

  • Faktor:
    1. Mekanis
    2. Kimiawi
    3. Neuronal
    4. Psikis
    5. Rangsangan sakit

• Sistem Imun Spesifik

  • Protein-Enzim
    • Enzim lisozomal
    • Laktoferrin
    • Musin
    • Interferon
      • leukosit
      • fibroblast
      • limfosir
    • sitokin
  • Kelenjar air/saliva → sIGA
    • komponen seluler :
      • PMN neutrofil, makrofag,
      • sel T, sel B
    • komponen humoral :
      • sIgA (200mg/L/hari),
      • IgG (1,4mg/dL),
      • IgM (0,2mg/dL) , C